Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Evaluation of the clinical use and impact of Miao medicine's anti-influenza mask on IgA in human serum and SIgA in nasal mucosa

Menglong Wang¹, Yang Xiao¹, Zhiqiong Wang¹, Lin Gan¹, Xixi Zhou², Yiju Zeng¹

¹QianDongNanZhou Hospital of Traditional Chinese Medicine, Kaili, Guizhou 556000, China; ²Ethnic Medicine Research Institute of Qiandongnan Miao and Dong Autonomous Prefecture, Kaili, Guizhou 556000, China.

For correspondence:- Yiju Zeng Email: zyj13765521721@163.com

Accepted: 30 November 2023 Published: 31 December 2023

Citation: Wang M, Xiao Y, Wang Z, Gan L, Zhou X, Zeng Y. Evaluation of the clinical use and impact of Miao medicine's anti-influenza mask on IgA in human serum and SIgA in nasal mucosa. Trop J Pharm Res 2023; 22(12):2539-2544 doi: 10.4314/tjpr.v22i12.17

© 2023 The authors.
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Abstract

Purpose: To investigate the clinical use of anti-influenza mask of Miao medicine, and its effect on human serum immunoglobulin A (IgA) as well as nasal mucosa secretory immunoglobulin A (SIgA).

Methods: 500 patients without COVID-19 in QianDongNanZhou Hospital of Traditional Chinese Medicine from January 2020 to September 2022 were selected and randomly divided into study and control groups, with 250 patients in each group. Both groups wore masks for three months. Control group was given disposable medical surgical three-layer melt-blown non-woven masks, while study group was given Miao medicine anti-infection masks. Serum IgA and SIgA levels were compared before and after wearing masks in both groups.

Results: Prior to intervention, serum IgA and SIgA levels in nasal mucosa were not significantly different (p > 0.05). There were also no significant differences in blood IgA levels between control and study groups. Before wearing masks, the study group had higher levels of blood IgA and nasal mucosal SIgA than control group. After wearing masks, nasal mucosa SIgA antibody levels and blood IgA antibody levels were significantly higher in the study group compared to control group (p < 0.001). The frequency of adverse responses did not significantly differ between the two groups (p > 0.05).

Conclusion: Miao medicine anti-infection masks are safe and raise serum levels of COVID-19 IgA antibodies and nasal mucosa SIgA levels in populations susceptible to COVID-19. These properties need to be compared among different races for the purpose of validation.

Keywords: Miao medicine, Mask, COVID-19, Immunoglobulin A, Secretory immunoglobulin A